Traits Prediction - Information
Traits Prediction Report ExampleA report page for each trait contains three main sections.
First, your predicted score based on the uploaded genotype file and published research:
Second, a report of how the genetic variants of the genotype file are involved in determining the predicted score.
Third, a table with detailed information about the most significant genetic variants from the genotype file.
Read below for explanations about each section.
Frequently Asked Questions
- In the menu page, what does the Please Complete Survey message mean?
- In the menu page, what does Confidence mean?
- In the menu page, what does the Survey Submitted column mean?
- In the trait report, how do I interpret the effect sizes histogram?
- In the trait report, why are columns in the table empty?
- In the trait report, what does my ancestry group under Frequency mean?
- In the trait report, what is an Effect Size?
- In the trait report, what is an Odds Ratio?
- In the trait report, what is a Standard Error?
- In the trait report, what is a P-Value?
- What if my prediction is wrong or inaccurate?
In the menu page, what does the Please Complete Survey message mean? (top)
In the menu page, what does Confidence mean? (top)
For more technical information see the Fraction of Variance Unexplained Wikipedia Page .
In the menu page, what does the Survey Submitted column mean? (top)
In the trait report, why are columns in the table empty? (top)
In the trait report, how do I interpret the effect sizes histogram? (top)
BLUE bars represent the maximum potential effect.
If the BLUE bar extends to the right of the 0.0 line, the SNP has potential to increase the predicted score.
If the BLUE bar extends to the left of the 0.0 line, the SNP has potential to decrease the predicted score.
If the BLUE bar extends to both sides, the SNP has potential to both increase and decrease the predicted score.
Information about BLUE bars is determined from published research.
RED bars represents the contribution of your
genotypes to the predicted score.
If the RED bar extends to the right of 0.0 line, this raises your score relative to the average.
If the RED bar extends to the left of 0.0 line, this lowers your score relative to the average.
Information in RED bars comes from your genotype file.
rs1: This SNP has the potential to increase your trait score (blue bar extend to the far right), but you either do not possess the effect allele, or the effect allele is highly common in your ancestry group (red bar extends only a little).
rs2: You possess the maximum possible effect contributed by this SNP.
rs3: This SNP has the potential to decrease your trait score, and your genotype results in a modest effect.
rs4: The effect of this SNP on your trait score can be either positive or negative depending on your ancestry group, and it contributes a small positive effect to your prediction.
This plot shows the effect contributed by each SNP to your prediction. For each SNP, this effect is determined by how many effect alleles you possess (0, 1, or 2), the effect size of the SNP, and the frequency of the effect allele in your ancestry group. Each bar on the y-axis represents one SNP. The x-axis represents the effect of the SNP and can be interpreted as a distance in standard deviations from the mean trait score on a standard normal distribution. For example, one standard deviation when predicting height amounts to about 6.5 cm.
The blue bar represents the maximum possible effect an individual can experience from a single SNP, though the vast majority of people may not see this effect. The red bar represents your effect from this SNP. When the red bar eclipses, the blue one, this means you possess the maximum effect of this SNP in either the positive or negative direction for the trait, given your alleles and ancestry. Above are some common scenarios you will see in your reports. The definition of a 'positive' effect depends on the trait - this could mean a taller predicted height, or a higher likelihood of having a genetic disorder.
The effect sizes histogram displays at most 30 SNPs with
the largest contributions to your score. This means that different
users may see different SNPs displayed, and that many of the SNPs
will be homozygous (as homozygous SNPs commonly contribute to a
Your prediction score is always calculated using the full set of known associated SNPs, which may number in the hundreds.
In the trait report, what does my ancestry group under Frequency mean? (top)
In the trait report, what is an Effect Size? (top)
In the trait report, what is an Odds Ratio? (top)
In the trait report, what is a Standard Error? (top)
In the trait report, what is a P-value? (top)
What if my prediction is wrong or inaccurate? (top)
Traits prediction based on genetic information is complicated by a wide variety of factors, including environmental effects, population stratification and statistical uncertainty, among other causes. Some of the predictions shown might be inaccurate. To keep improving our prediction models we ask our users to complete a preliminary survey - these surveys will enable us to refine our predictions.
If your prediction is inaccurate - we will use the valuable information you've provided in the survey to improve our future prediction models.
For any questions, please contact DNA.Land.Back